Irf3 transcription factor

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August undefined, 2024

WebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation of the transcription factor interferon regulatory factor 3 (IRF3) and consequent induction of host immune responses to RNA viruses. WebNov 20, 2024 · Interferon Regulatory Factors (IRFs) are a family of transcription factors that signal downstream of multiple pathways, including Toll-like receptor (TLR), retinoic acid-inducible gene I (RIG-I), melanoma differentiation associated gene 5 (MDA5), and B cell receptor (BCR) signaling pathways to regulate gene expression involved in both innate …

IRF and STAT Transcription Factors - From Basic Biology …

WebThe downstream signaling pathways from PRR activation phosphorylate ubiquitously expressed IRFs (IRF1, IRF3, and IRF7) through IRF kinases, such as TANK-binding kinase 1 … IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association … See more Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. See more IRF3 has been shown to interact with IRF7. See more • Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth" See more • Interferon+Regulatory+Factor-3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook IRF3 See more dxb to nepal flight

IRF3 - Interferon regulatory factor 3 - Function

WebJul 25, 2024 · The discovery Interferon-regulatory factor 3 (IRF3) and IRF7 are the two pivotal transcriptional factors that directly control the production of IFN-α and IFN-β, determining the antiviral... WebJun 19, 2012 · Given that IRF3 acts as a transcription activator for promoters of genes encoding type I interferons but not for the Il12b promoter, it will be useful to explore the molecular mechanism by... WebNov 1, 2012 · IRF3 and IRF7 have multiple sites that—upon viral infection—are substrates for phosphorylation by the serine/threonine kinases TANK-binding kinase 1 (TBK1) and IκB … dxb to ruh flight schedule

A protective role of IRF3 and IRF7 signalling downstream TLRs in …

IRF3 inhibits nuclear translocation of NF-κB to prevent viral ...

WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … WebJan 8, 2024 · Transcriptional activation of the IFNβ promoter by IRF3/7 has been extensively studied (9, 10), and proceeds with phosphorylation of IRF3/7 by the kinase TKB1, leading … crystal mn pickleballWebInterferon regulatory factor 3 (IRF3) is a key transcription factor activated in response to virus infection and is largely responsible for establishing an antiviral state in the infected... crystal mn non emergency police

"WebMay 31, 2024 · IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which is ubiquitously expressed in a variety of … " - Irf3 transcription factor

Irf3 transcription factor

Frontiers Therapeutic Targeting of IRFs: Pathway-Dependence or ...

WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other … WebIRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. Following virus infection, IRF-3 is posttranslationally modified by protein phosphorylation at multiple serine and threonine residues, located in the carboxy-terminus of IRF-3.

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WebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear … WebMar 29, 2024 · IRF3 is activated by phosphorylation (by kinases TBK1 and IKKε), promoting dimerization, nuclear translocation, association with the co-activator CREB-binding protein …

WebApr 14, 2003 · The transcription factors interferon regulatory factor 3 (IRF3) and NF-κB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of ... WebJun 1, 2024 · The interferon regulatory factor (IRF) family of transcription factors play a vital role in the human innate antiviral immune responses with production of (IFNs) as a hallmark outcome of activation. In recent years, IRF3 Graphical abstract Keywords IKKε NAP1 TBKBP1 TANK Abbreviations IRF Interferon regulatory factor IFNs Interferons TI-IFNs

WebJan 8, 2024 · The mammalian IRF family proteins are structurally related transcription factors consisting of nine members: IRF1, IRF2, IRF3, IRF4 (also called ICSAT [IFN consensus sequence-binding protein for activated T-cells], LSIRF [lymphocyte-specific IRF], PIP [PU.1-interacting protein]), IRF5, IRF6, IRF7, IRF8 (also referred to ICSBP [IFN … WebOct 15, 2024 · Using two model transcription factors, IRF3 and STAT1, we demonstrate that transcription factor dimerization enables the trans-autoacetylation of p300 in a highly …

WebPreviously, it was shown that IRF3 is a downstream transcription factor that regulates the expression of IFNβ induced by TRIF-dependent TLRs 28, 29. ... 22, via the inhibition of NLRP1 and NLRP3 inflammasome, or via induction of IL-10 who then through activation of STAT3 transcription factor reduced the abundance of pro-IL-1a and pro-IL-1β.

crystal mn poolWebTranscription factors IRF3 activates toll-like receptor-independent type I IFN production, which are very important in inducing IFN-γ production. 32 IFN-α/β is one of the most … crystal mn new police stationWebIRF-3 is expressed constitutively in a variety of tissues, and the relative levels of IRF-3 mRNA do not change in virus-infected or IFN-treated cells. Following virus infection, IRF-3 is … dxb to phuketWebThe transcription factor IFN regulatory factor 3 (IRF3) plays an essential role in this process (3, 4). It was also reported that IRF3 is required to protect the host from viral infections, … dxb to ruh flightsWebIRF3 is a transcription factor which is a major regulator of the type I interferon (IFN) antiviral response after recognition of viral DNA or RNA by intracellular foreign nucleic acid sensors, such as Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and cyclic GMP-AMP synthase (cGAS) (reviewed in [10]). IRF3 activa- crystal mn police phoneWebOct 15, 2024 · Transcription factors for expression of IRF3 engage its gene locus located on human chromosome 19q13.3–13.4 . The structural gene is composed of eight exons, which include a 5′UTR. Several laboratories uncovered critical domains of … dxb to sea flight pathWebMay 31, 2024 · IRF3 (interferon regulatory factor 3) serves as an indispensable transcription factor for type I IFN production. After receiving upstream signals, IRF3 goes through diverse processes to activate the type I IFN signaling, including phosphorylation, dimerization, translocation to nucleus and stimulation of DNA binding and transcriptional activity ... crystal mn police reports