Multidrug resistance-associated protein 1
Web"The human multidrug resistanceprotein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs". Proc Natl Acad Sci U S A. 100 (16): 9244–9. Bibcode: 2003PNAS..100.9244R. doi: 10.1073/pnas.1033060100. PMC 170903. PMID 12835412. Web6 dec. 1999 · The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug …
Multidrug resistance-associated protein 1
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Web10 aug. 2024 · Multidrug resistance (MDR) is the major cause, by which cancer cells expel the drugs out, developing a challenge against the current chemotherapeutic drugs regime. This mechanism is attributed... WebMultidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 …
WebAcum 2 zile · Antibiotic resistance (AR) is posing a serious threat to the global health. By accumulating intrinsic resistant mutations or horizontally transferred AR genes, bacteria … WebMultidrug Resistance associated protein 1 (MRP1, or ABCC1) is a 190kDa ABC transporter presenting three membrane spanning domains comprising 17 …
Web10 aug. 2011 · MRP1 was first discovered in an anthracycline-resistant cell line HL60/Adr which was the first major ABC transporter other than P-gp. This protein was shown to … Web16 aug. 2000 · In 1992, Cole et al. (5) discovered a second type of drug pump in MDR cancer cells, the multidrug resistance-associated protein (MRP). While the human genome encodes only two P-gp's (6) [and a distant relative of P-gp, the bile salt transporter (7) ], it is shown to contain many more genes related to MRP (8,9).
WebFrom the structural point of view, only the bovine ortholog of the multidrug-resistance associated protein 1 (bMRP1) has been resolved. We here used ms-scaled molecular dynamics simulations to investigate the structure and dynamics of bMRP1 in pre- and post-hydrolysis functional states. The present work aims to examine the slight but likely ...
WebSeveral members of the multidrug resistance‐associated protein family serve as export pumps that prevent the accumulation of anionic conjugates and GSSG in the cytoplasm, and play, therefore, an essential role in detoxification and defense against oxidative stress. frog smartchlor cartridge inline instructionsWebMultidrug resistance protein 1 and multidrug resistance-associated protein 1 are transporters that efflux diverse xenobiotics from cells. We investigated changes in the expression and activity of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in highly purified lung dendritic cells (LDCs) during aging using … frog smart ease smartchlor cartridgeWeb5 ian. 2024 · NM_102777.3 → NP_174329.1 multidrug resistance-associated protein 1 [Arabidopsis thaliana] See identical proteins and their annotated locations for … frogs lungs functionWeb4 apr. 2006 · There are now nine members of the multidrug resistance-associated protein family and eight of these (MRP1–8) are known to be organic anion transporters. Between them, the MRPs can transport a large range of organic anions, including anionic drugs and drugs conjugated to glutathione (GSH), sulfate, or glucuronate. frog small intestine descriptionWeb9 aug. 2024 · MDR is typically associated with transmembrane proteins mediating efflux of administered drugs, thereby keeping their intracellular concentration below the threshold required to kill cells. Although expression assays based on flow cytometry and immunostaining have shown that multidrug resistance-associated protein 1 (MRP1) is … frog small intestines functionWeb7 nov. 2014 · The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is … frog smartchlorfrog small image