Topcat trial pubmed

Author: xgue

August undefined, 2024

Web8. aug 2024 · The TOPCAT trial showed no benefit for spironolactone in heart failure patients with preserved ejection fraction (HFpEF). Post-hoc, spironolactone helped … Web6. jan 2024 · TOPCAT was conducted with the approval of local institutional review boards. The design and primary findings have been published. 14, 15 Patients with symptomatic heart failure and a left ventricular ejection fraction ≥45% who provided written informed consent were eligible.

[PDF] Interaction Between Spironolactone and Natriuretic Peptides …

Web10. apr 2014 · Aldosterone Antagonist (TOPCAT) trial is provided in the Supplementary Appen-dix, available at NEJM.org. This article was updated on April 10, 2014, at NEJM.org. N Engl J Med 2014;370:1383-92. WebTOPCAT enrolled patients with left ventricular EF≥45%, which is below accepted diagnostic cut-offs for HFpEF; sensitivity analysis restricted to patients with left ventricular EF≥50% … hersan hillcon

Spironolactone Metabolites in TOPCAT — New Insights into …

Web2. aug 2016 · More recently, spironolactone has been evaluated in the National Heart, Lung, and Blood Institute (NHLBI) sponsored TOPCAT trial 26 in which 3445 patients with chronic HF with a preserved left ventricular ejection fraction (HF-PEF) were randomized to spironolactone in a dosing strategy starting with 15 mg/day with possible up titration to … Web19. jan 2015 · Given the marked regional variation in event rates observed in the TOPCAT trial, we performed a separate pooled analysis, excluding patients randomized into TOPCAT trial from Russia and the republic of Georgia. Web12. apr 2024 · In the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, which included patients with a systolic BP (SBP) up to 160 mmHg, rates of the primary ... hers anxiety medication reviews

Total or Partial Knee Arthroplasty Trial - TOPKAT: study protocol …

The new england journal medicine

Web22. mar 2024 · Hypokalemia occurs commonly in chronic heart failure consequent to neurohormonal activation and diuretic therapy.1 Clinicians chase potassium levels with potassium supplementation, risking hyperkalemia when renal dysfunction ensues. Scientific rigor is lacking to define the optimal potassium level, the appropriate pace of correction … Web10. apr 2014 · Lessons from the TOPCAT Trial NEJM Home Specialties Specialties Allergy/ Immunology Cardiology Clinical Medicine Dermatology Emergency Medicine … hers and theirs mugsWeb31. okt 2024 · TOPCAT was a multicentre, randomized, double-blind, placebo-controlled trial that tested the efficacy of spironolactone to reduce CV morbidity and mortality in 3445 adults ≥50 years of age with HFpEF (LVEF ≥45%). 5 Key exclusion criteria relevant to this analysis included severe lung disease requiring home O 2 or systemic steroid therapy ... hers anxiety medication

"Web15. sep 2015 · The recently completed TOPCAT trial enrolled HFpEF patients with LVEF ≥45%. 6 Spironolactone did not reduce the primary outcome of heart failure hospitalization, ... Related articles in PubMed. Characteristics and outcomes in acute myocardial infarction hospitalizations among the older population (age =80 years) in the United States, 2004 ... " - Topcat trial pubmed

Topcat trial pubmed

Denervation or stimulation? Role of sympatho-vagal imbalance in …

Web6. júl 2024 · In this issue of the Journal, Ferreira and colleagues, in a post-hoc analysis of the TOPCAT Americas cohort of patients with HFpEF, provide additional insights on the titration and discontinuation of spironolactone and the dose–response association between spironolactone and clinical events. 15 Ferreira et al. report that, during the first year … Web16. nov 2024 · TOPCAT study design and objectives The design of the TOPCAT study has been described in detail previously. 10 Briefly, TOPCAT was a multi-centre, international, randomized, double blinded, placebo-controlled trial of spironolactone in adults with HFpEF recruited from over 270 clinical sites.

Did you know?

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 Web12. sep 2024 · Methods: The baseline self-reported PA of 1751 subjects enrolled in the Americas region of the TOPCAT trial (Treatment of Preserved Cardiac Function Heart …

WebIn TOPCAT, women and men presented with different clinical profiles and similar clinical outcomes. The interaction between spironolactone and sex in TOPCAT overall and in the … Web1. mar 2024 · Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) Abstract Despite improvements in the prognosis of patients with heart failure with reduced ejection fraction (HFrEF), established therapy for heart failure patients with preserved ejection fraction (HFpEF) is lacking.

Web1. apr 2024 · @article{Anand2024InteractionBS, title={Interaction Between Spironolactone and Natriuretic Peptides in Patients With Heart Failure and Preserved Ejection Fraction: From the TOPCAT Trial.}, author={Inder S. Anand and Brian Lee Claggett and Jiankang Liu and Amil M. Shah and Thomas S. Rector and Sanjiv J. Shah and Akshay S. Desai and Eileen O ... Web10. apr 2014 · Aldosterone Antagonist (TOPCAT) trial is provided in the Supplementary Appen-dix, available at NEJM.org. This article was updated on April 10, 2014, at …

WebObjective: The TOPCAT trial is designed to evaluate the effect of spironolactone, an aldosterone antagonist, on morbidity, mortality, and quality of life in patients with HF-PEF. …

Web6. jan 2015 · Background: Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) patients with heart failure and preserved left … hersan veterinaire cognacWeb10. nov 2024 · To study post-randomization weight changes and how these could impact outcomes and the effect of spironolactone in patients with HFpEF enrolled in the TOPCAT-Americas trial (N = 1767). Mixed-effects regressions and time-updated Cox models to assess the factors associated with weight changes and their impact on subsequent … mayapur iskcon schoolWebMethods and results: Using data from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, a frailty index (FI) was … hers anxiety medsWeb9. sep 2016 · TOPCAT was a phase III, multicentre, international, randomized, double‐blind, placebo‐controlled trial. Patients were eligible if they were ≥50 years of age, exhibited at least one sign and one symptom of HF, and had an LVEF of ≥45%. hers anxiety medicineWeb2. dec 2024 · Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) Abstract Importance: β-Blockers are prescribed to most patients with heart failure (HF) with a preserved ejection fraction (HFpEF), but their effect on HFpEF remains unclear. mayapur iskcon new templeWeb24. jún 2024 · As such, the National Heart, Lung, and Blood Institute sponsored the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial, a phase 3, international, double-blind, placebo-controlled trial of spironolactone in patients with HFpEF [ 8 ••]. hers anxiety pillsWeb10. apr 2014 · Methods: In this randomized, double-blind trial, we assigned 3445 patients with symptomatic heart failure and a left ventricular ejection fraction of 45% or more to … mayapur iskcon mandir guest house